Abstract
In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Membrane / metabolism
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Drug Design
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Drug Evaluation, Preclinical / methods
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Hypothalamus / drug effects
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Hypothalamus / metabolism
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Models, Molecular*
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Rats
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Receptors, Serotonin / chemistry
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Reproducibility of Results
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Serotonin Antagonists / chemistry*
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Serotonin Antagonists / metabolism
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Serotonin Antagonists / pharmacology*
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Structure-Activity Relationship*
Substances
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Receptors, Serotonin
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Serotonin Antagonists
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serotonin 7 receptor